What should be the dosage of Oxycodone Dosage. Oxycodone is a powerful medication that is often used to manage moderate to severe pain. It is an opioid pain reliever that works by binding to specific receptors in the brain and spinal cord, which can reduce the sensation of pain.The appropriate oxycodone dosage is determined by a healthcare provider based on several factors, including the patient's medical history, the severity of the pain, and their response to previous pain medications. Taking the right dose of oxycodone can help relieve pain and improve the patient's quality of life. However, it is crucial to use oxycodone only as prescribed and not to exceed the recommended dose. Overdosing on oxycodone can cause severe respiratory depression, coma, and even death. In addition, using oxycodone long-term or at high doses can lead to physical dependence and addiction, which can be challenging to overcome.Therefore, it is essential to use oxycodone responsibly and only under